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Immune defense relies on the capacity to respond to an ever-changing spectrum of pathogens and cancers while maintaining tolerance to self. The Koh Lab focuses on understanding the design principles in immune development that allow flexibility in cellular fate and function. We employ an interdisciplinary approach combining genetics, genomics, biochemistry, proteomics, and computational modeling with particular emphasis on interrogating chromatin state, gene expression, and protein composition from the same single cell. Elucidating the molecular underpinnings of cellular plasticity will provide insights into disease mechanisms and avail new therapies for human disorders.
mirroring the periphery for immune tolerance
t cell plasticity and Leukemogenesis
chromatin and epigenesis