KOH LAB

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Cellular identities allow coordination of specialized systems that provide organismal homeostasis. Phenotypic deviation from established identities is a hallmark of tumorigenesis, but it can also facilitate tissue repair and adaptation to changing environments. The Koh Lab focuses on understanding the design principles regulating cell fate stability versus plasticity. A major area of interest is the role of chromatin in specifying the range of phenotypes that can be sampled through the integration of intrinsic and extrinsic cues such as transcription factor activity, chromatin remodeling, signal transduction and metabolism. We employ an interdisciplinary approach combining genetics, genomics, biochemistry, proteomics, and computational modeling to elucidate how cellular plasticity is leveraged to promote homeostasis and is exploited for tumorigenesis.