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Immune defense relies on the capacity to respond to ever-changing pathogens and cancers while maintaining tolerance to self. The Koh Lab focuses on understanding the design principles that allow flexibility in cellular fate and function. A major area of interest is the role of chromatin in specifying the range of cellular fates that can be sampled by a somatic cell, with an emphasis on chromatin remodeling complexes and their interface with transcription factors. We employ an interdisciplinary approach combining genetics, genomics, biochemistry, proteomics, and computational modeling to elucidate how cellular plasticity is leveraged to promote immunity and exploited for oncogenesis.
mirroring the periphery for immune tolerance
t cell plasticity and Leukemogenesis
chromatin and epigenesis