KOH LAB @ UCHICAGO
 

epigenesis of immune plasticity

KOH LAB

 
 
Jason Holley Cropped sig.jpg

WELCOME!

Immune defense relies on the capacity to respond to an ever-changing spectrum of pathogens and cancers while maintaining tolerance to self. The Koh Lab focuses on understanding the design principles in immune development that allow flexibility in cellular fate and function. We employ an interdisciplinary approach combining genetics, genomics, biochemistry, proteomics, with particular emphasis on developing methods that interrogate chromatin accessibility, gene expression, and surface proteins from the same single cell. Elucidating how cellular plasticity is programmed in development, and dysregulated in disease, will avail novel therapeutic avenues for human disorders.

mirroring the periphery for immune tolerance

t cell plasticity and Leukemogenesis

chromatin and epigenesis